Réaction #1502

Équation de réaction

Chloromethyl chloroformate

cholesterol

Pyridine

→

3-(Chloromethoxycarbonyl) Cholesterol

Solvants

CH2Cl2

CH2Cl2

Conditions de réaction

Traitement

1. 1
   TempératureThe solution was cooled
2. 2
   TempératureHeat
3. 3
   Autrewas produced
4. 4
   Autrethe reaction gave a clear solution from
5. 5
   Lavagewashed with 0.5M HCl (50 ml) and water (3×25 ml)
6. 6
   AutreAfter treatment with MgSO4, the solution was evaporated to dryness

Mode opératoire

Chloromethyl chloroformate (1.96 g, 15.2 mmol) and cholesterol (5.0 g, 12.9 mmol) was dissolved in CH2Cl2 (10 ml). The solution was cooled. Pyridine (1.21 g, 15.3 mmol) was dripped into the stirred solution over 5 minutes. Heat was produced and the reaction gave a clear solution from a somewhat unclear starting solution. After 24 hours at room temperature, the mixture was diluted with CH2Cl2 (50 ml), washed with 0.5M HCl (50 ml) and water (3×25 ml). After treatment with MgSO4, the solution was evaporated to dryness.

Source