Réaction #1483085

Équation de réaction

pTSA

DL-alanine

dodecanol 2

→

dodecyl 2-aminopropanoate

Rendement 110.8%

Dodecyl 2-aminopropanoate

Rendement 110.8%

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONAfter addition
2. 2
   Températurethe temperature of the reaction mixture was slowly raised
3. 3
   Températureto reflux temperature
4. 4
   Autrethe water was separated azeotropically
5. 5
   ConcentrationThe reaction mixture was concentrated under vacuum
6. 6
   Lavagewashed with aqueous 5% Na2CO3 (3×50 mL)
7. 7
   SéchageThe organic layer was dried over Na2SO4
8. 8
   Concentrationconcentrated under vacuum

Mode opératoire

To a stirred solution of DL-alanine 1 (5 g, 56.1 mmol) in toluene (100 mL) was added dodecanol 2 (9.42 g, 50.5 mmol) in one lot, followed by pTSA (11.75 g, 61.7 mmol). After addition, the temperature of the reaction mixture was slowly raised to reflux temperature, the water was separated azeotropically, and the reaction mixture was monitored by TLC. The reaction mixture was concentrated under vacuum, the obtained residue was taken in ethyl acetate (200 mL) and washed with aqueous 5% Na2CO3 (3×50 mL) followed by brine solution. The organic layer was dried over Na2SO4 and concentrated under vacuum to afford crude dodecyl 2-aminopropanoate 3 (14.4 g, yield: 100%) as a liquid.

Source