Réaction #1483075

Équation de réaction

1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester

→

3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester

Rendement 92.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe catalyst was removed by filtration
2. 2
   Autrethe solvents removed in vacuo

Mode opératoire

A mixture of 1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester (0.23 g, 0.71 mmol), Pd (10% on carbon, 30 mg) and methanol (5 mL) was stirred under a hydrogen atmosphere (ballon) for 6 hr. The catalyst was removed by filtration and the solvents removed in vacuo to provide of 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester (0.19 g, 92% yield).

Source