Réaction #1470439

Équation de réaction

Succinic anhydride

2,6-diisopropylphenol

→

2,6-diisopropylphenyl hydrogen succinate

Rendement 80.2%

Solvants

triethylamine

Conditions de réaction

Traitement

1. 1
   Autresolvents were removed under vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   workup.ADDITIONadded to an iced solution of dilute hydrochloric acid
4. 4
   FiltrationThe precipitated product was filtered
5. 5
   Autrerecrystallized from ethanol-water

Mode opératoire

Succinic anhydride (14 g, 140 mmol) and dimethylaminopyridine (0.02 g, 0.16 mmol) were added to a solution of 2,6-diisopropylphenol (20.8 ml, 112 mmol) in triethylamine (50 ml) under nitrogen. After 16 hr at room temperature, solvents were removed under vacuum. The residue was dissolved in water and added to an iced solution of dilute hydrochloric acid. The precipitated product was filtered and recrystallized from ethanol-water to yield 25.0 g (80.2% yield) of 2,6-diisopropylphenyl hydrogen succinate (propofol hemisuccinate), mp 101-102° C.

Source