Réaction #1462262

Équation de réaction

[2-(4-acetylamino-phenyl)-1,3-dihydroxy-indan-2-yl]-acetic acid ethyl ester

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title compound

Rendement 85.3%

[2-(4-Acetylamino-phenyl)-indan-2-yl]-acetic acid ethyl ester

Rendement 85.3%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Autrethe flask was evacuated
2. 2
   workup.ADDITIONhydrogen was introduced into the flask via a balloon
3. 3
   Filtrationwas filtered through Hi-flow supercel
4. 4
   ConcentrationThe filtrate was concentrated
5. 5
   workup.ADDITIONthen diluted with ethyl acetate (100 mL)
6. 6
   LavageThis solution was washed with saturated sodium hydrogen carbonate solution (100 mL)
7. 7
   Séchagewith water (100 mL), then dried over magnesium sulfate
8. 8
   Autreevaporated

Mode opératoire

A stirred solution of [2-(4-acetylamino-phenyl)-1,3-dihydroxy-indan-2-yl]-acetic acid ethyl ester (0.38 g, Reference Example 12) in acetic acid (20 mL), under nitrogen, was treated with palladium black (20 mg), then the flask was evacuated and then hydrogen was introduced into the flask via a balloon. After stirring at 50° C. for 2 days the reaction mixture was filtered through Hi-flow supercel. The filtrate was concentrated then diluted with ethyl acetate (100 mL). This solution was washed with saturated sodium hydrogen carbonate solution (100 mL), then with water (100 mL), then dried over magnesium sulfate and then evaporated to give the title compound (0.296 g) as an amber coloured gum.

Source