Réaction #1447111

Équation de réaction

Et3N

1-naphthol

phosphorus oxychloride

→

title compound

1-Naphthyl dichlorophosphate

Solvants

Et2O

Conditions de réaction

Traitement

1. 1
   workup.WAITthe resulting solution was left
2. 2
   Températureto warm to RT overnight
3. 3
   FiltrationThe white slurry was filtered under an inert atmosphere
4. 4
   Autreall volatiles were removed

Mode opératoire

To 1-naphthol in Et2O (0.23 M) was added phosphorus oxychloride (1.0 eq.) and the solution was cooled to −78° C. Neat Et3N (1.0 eq) was added and the resulting solution was left to warm to RT overnight. The white slurry was filtered under an inert atmosphere and all volatiles were removed to yield the title compound as a colorless liquid that was used without further purification in the next step. 31P NMR (400 MHz, CDCl3): δ 3.93 ppm.

Source