Réaction #1447102

Équation de réaction

KOtBu

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene

KOtBu

HCl

cyclobutanol

→

title compound

1-Bromo-4-cyano-3-cyclobutoxy-5-(4-ethyl-phenyl)-benzene

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONcharged with a stir bar
2. 2
   workup.ADDITIONis added
3. 3
   ExtractionThe resulting mixture is extracted with ethyl acetate
4. 4
   Séchagethe combined organic phases are dried (sodium sulphate)
5. 5
   Autrethe solvent is removed

Mode opératoire

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene (1.2 g) is added to a flask charged with a stir bar, KOtBu (0.5 g) and cyclobutanol (3.0 g). The solution is stirred at room temperature overnight, before another portion of KOtBu (0.2 g) is added. The solution is stirred for another 5 h and then neutralized with 1 M aqueous HCl solution. The resulting mixture is extracted with ethyl acetate, the combined organic phases are dried (sodium sulphate) and the solvent is removed to give the title compound.

Source