Réaction #1447098

Équation de réaction

hydrochloric acid

N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide

→

title compound

4-Bromo-2-(4-ethyl-benzyl)-5-methoxy-phenylamine

Solvants

isopropanol

Conditions de réaction

Traitement

1. 1
   TempératureThe solution is heated
2. 2
   Températureat reflux temperature for 8 h
3. 3
   Concentrationconcentrated under reduced pressure
4. 4
   Autreto remove most of the alcohol
5. 5
   workup.ADDITIONAqueous NaHCO3 solution is added to the rest
6. 6
   Extractionthe resulting mixture is extracted twice with ethyl acetate
7. 7
   LavageThe combined organic extracts are washed with brine
8. 8
   Séchagedried (Na2SO4)
9. 9
   Concentrationconcentrated

Mode opératoire

Half-concentrated hydrochloric acid (5 mL) is added to a solution of N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide (2.8 g) in isopropanol (20 mL). The solution is heated at reflux temperature for 8 h and then concentrated under reduced pressure to remove most of the alcohol. Aqueous NaHCO3 solution is added to the rest and the resulting mixture is extracted twice with ethyl acetate. The combined organic extracts are washed with brine, dried (Na2SO4) and concentrated to give the title compound.

Source