Réaction #1427

Équation de réaction

Potassium bromide

D-leucine

sodium nitrite

→

crude title product

(S)-2-Bromo-4-methylpentanoic acid

Solvants

sulfuric acid

Conditions de réaction

Traitement

1. 1
   Températuremaintaining the temperature between -10° and -5° C
2. 2
   workup.ADDITIONAfter addition
3. 3
   Températurewarmed to room temperature
4. 4
   workup.STIRRINGstirred for another hour
5. 5
   ExtractionThe reaction mixture was then extracted twice with ether
6. 6
   Lavagethe ether extracts were washed once with water
7. 7
   Séchagedried (magnesium sulfate)
8. 8
   Filtrationfiltered
9. 9
   Autreevaporated
10. 10
    Autreto give 2.7 g

Mode opératoire

Potassium bromide (9.5 g., 80 mmol.) was added to a stirred solution of D-leucine (3.0 g., 23 mmol.) in 2.5N sulfuric acid (47 ml.) at room temperature. The reaction mixture was cooled to -10° C. and solid sodium nitrite (2.4 g., 34 mmol.) was added portionwise, maintaining the temperature between -10° and -5° C. After addition was complete, the reaction was stirred for 1 hour and then warmed to room temperature and stirred for another hour. The reaction mixture was then extracted twice with ether, the ether extracts were washed once with water, dried (magnesium sulfate), filtered and evaporated to give 2.7 g. of crude title product.

Source