Réaction #1384831

ord-342a350a10444c7ba59ef68482c16b75

Équation de réaction

CCOc1c(C#N)cnc2ccc(/C=C3\SC(SC)=NC3=O)cc12
4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile
COCCOCCN
2-(2-methoxy-ethoxy)-ethylamine
CCN(C(C)C)C(C)C
DIEA
→
CCOc1c(C#N)cnc2ccc(/C=C3\SC(NCCOCCOC)=NC3=O)cc12
6-[2-[2-(2-methoxy-ethoxy)-ethylamino]-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-ethoxy-quinoline-3-carbonitrile

Réactifs

CCOc1c(C#N)cnc2ccc(/C=C3\SC(SC)=NC3=O)cc12
4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile
COCCOCCN
2-(2-methoxy-ethoxy)-ethylamine
CCN(C(C)C)C(C)C
DIEA

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), 2-(2-methoxy-ethoxy)-ethylamine and DIEA to give 6-[2-[2-(2-methoxy-ethoxy)-ethylamino]-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-ethoxy-quinoline-3-carbonitrile. LC-MS m/e 427 (MH+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07250515B2uspto-grants-2007_07