Réaction #1379897

Équation de réaction

2-(2-aminoethylamino)ethanol

benzyl acrylate

→

2-(benzyloxycarbonylethyl]-2-(2aminoethylamino)ethanol

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureat reflux for 24 hours
3. 3
   AutreThe excess reagent was removed under reduced pressure
4. 4
   Autrethe resulting oil was purified by flash chromatography
5. 5
   workup.ADDITIONa mixture of dichloromethane and ethyl acetate (60:40)
6. 6
   Lavageto elute the desired material
7. 7
   AutreFractions were collected

Mode opératoire

A solution of 2-(2-aminoethylamino)ethanol (4.6648 g; 44.8 mmole) dissolved in 35 mL of benzyl acrylate was heated at reflux for 24 hours. The excess reagent was removed under reduced pressure and the resulting oil was purified by flash chromatography using a mixture of dichloromethane and ethyl acetate (60:40) to elute the desired material. Fractions were collected and analyzed to determine which of these contain the product. Solvents were eliminated under vacuum to give 5.8 g (21.9%) of N,N,N′-tris[2-(benzyloxycarbonylethyl]-2-(2aminoethylamino)ethanol (8).

Source