Réaction #1379895

Équation de réaction

acryloyl chloride

O-benzyl hydroxylamine hydrochloride

Water

→

N-benzyloxyacrylamide

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Autrethe layers were separated
2. 2
   LavageThe organic solution was washed with diluted hydrochloric acid
3. 3
   SéchageThe organic layer was dried over magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   Autrethe solvent removed under reduced pressure
6. 6
   AutreThe residue was purified by flash chromatography
7. 7
   workup.ADDITIONa mixture of hexane and ethyl acetate
8. 8
   AutreThe purification

Mode opératoire

A solution of acryloyl chloride dissolved in dry dichloromethane was cooled at 0° C. with an ice bath. A mixture of O-benzyl hydroxylamine hydrochloride (29) and N,N-diisopropylethylaamine in dry dichloromethane was added. Water was added and the layers were separated. The organic solution was washed with diluted hydrochloric acid, a saturated sodium bicarbonate solution, water, and brine. The organic layer was dried over magnesium sulfate, filtered, and the solvent removed under reduced pressure. The residue was purified by flash chromatography using a mixture of hexane and ethyl acetate. The purification gave N-benzyloxyacrylamide (30).

Source