Réaction #1371

Équation de réaction

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

Rendement 82.6%

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températurethe mixture is refluxed for 2.5 hours
2. 2
   TempératureAfter cooling
3. 3
   Extractionthe resultant is extracted with diethyl ether
4. 4
   Séchagethe extract is dried over magnesium sulfate
5. 5
   Concentrationconcentrated

Mode opératoire

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

Source