Réaction #1367

Équation de réaction

2-methylthiomethyl-3,4,6-trifluoroaniline

→

2-methyl-3,4,6-trifluoroaniline

Rendement 71.3%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   FiltrationAfter the catalyst is filtered off
2. 2
   workup.ADDITIONthe filtrate is added with water
3. 3
   Extractionextracted with dichloromethane
4. 4
   SéchageThe is dried over magnesium sulfate
5. 5
   Concentrationconcentrated

Mode opératoire

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

Source