Réaction #1352073

Équation de réaction

sodium hydroxide

compound

1-methyl-3,4-dihydroisoquinoline

sodium borohydride

hydrochloric acid

→

titled compound

Rendement 93.9%

1-methyl-1,2,3,4-tetrahydroisoquinoline

Rendement 93.9%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurecooled to below 5° C.
2. 2
   Extractionextracted with ethyl acetate
3. 3
   SéchageThe ethyl acetate layer was dried over anhydrous sodium sulfate
4. 4
   Concentrationconcentrated in vacuo

Mode opératoire

To the suspension of sodium borohydride (5.28 g, 138 mmol) in ethanol, was added the compound (19.8 g, 133.8 mmol) prepared in Step 2 above. The reaction mixture was stirred for 1 hour at room temperature, cooled to below 5° C. acidified with diluted hydrochloric acid, neutralized with sodium hydroxide solution, and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give 18.5 g of the titled compound.

Source