Réaction #1352072

Équation de réaction

ammonia

compound

N-(2-phenylethyl)acetamide

→

titled compound

Rendement 97.0%

1-methyl-3,4-dihydroisoquinoline

Rendement 97.0%

Conditions de réaction

Traitement

1. 1
   Extractionextracted with ethyl acetate
2. 2
   SéchageThe extract was dried over anhydrous magnesium sulfate
3. 3
   Concentrationconcentrated in vacuo

Mode opératoire

The compound (25.3 g, 154.8 mmol) prepared in Step 1 above was added to polyphosphoric acid (250 g) and then stirred for 1.5 hours at 160° C. The reaction mixture was poured into ice water, neutralized with ammonia solution, and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated in vacuo. The resulting residue was subjected to silica gel column chromatography (eluent: methanol/dichloromethane ={fraction (1/20)}) to give 21.8 g of the titled compound as an oily substance.

Source