Réaction #1340977

ord-743b476f845d4cebb8691bd3a5e7e018

Équation de réaction

Cc1cc(O)nc(C)c1Br
5-bromo-4,6-dimethyl-2-hydroxypyridine
Cc1ccc(S(=O)(=O)OCCC(C)(C)O)cc1
3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate
Cc1cc(OCCC(C)(C)O)nc(C)c1Br
compound
Rendement 70.1%
Cc1cc(OCCC(C)(C)O)nc(C)c1Br
4-(5-bromo-4,6-dimethylpyridin-2-yloxy)-2-methylbutan-2-ol
Rendement 70.1%

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

According to a method described in [WO 2009/054423 pamphlet, (Production Example 37)], from 5-bromo-4,6-dimethyl-2-hydroxypyridine (1.50 g) and 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate (2.11 g), the subject compound (1.50 g) was obtained as a colorless oil.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08455500B2uspto-grants-2013_06