Réaction #1332525

Équation de réaction

water

(R)-(−)-2-phenylglycine

carbamide

Et3N

→

6-phenyldihydropyrimidine-2,4(1H,3H)-dione

Conditions de réaction

Traitement

1. 1
   Températureby cooling to room temperature
2. 2
   Températurecool to room temperature
3. 3
   AutreProduct precipitated out of the solution
4. 4
   FiltrationThe product was collected by filtration
5. 5
   Autredried for use without purification

Mode opératoire

A neat mixture of (R)-(−)-2-phenylglycine (500 mg, 2.4795 mmol) and carbamide (2 g, 33.3 mmol) was heated to 150° C. Et3N (0.6913 mL, 4.959 mmol) was added after the mixture melted. Stirring was continued at 150° C. for 4 hours followed by cooling to room temperature. The product was dissolve in water at 100° C., then cool to room temperature. Product precipitated out of the solution. The product was collected by filtration and dried for use without purification.

Source