Réaction #1328424

Équation de réaction

methyl 2-hydroxy-4-methoxybenzoate

dichloromethoxymethane

→

methyl 2-hydroxy-3-formyl-4-methoxybenzoate

Rendement 42.4%

Solvants

methylene chloride

methylene chloride

Conditions de réaction

Traitement

1. 1
   Extractionextracted with methylene chloride
2. 2
   LavageThe combined organic phases were washed with sodium bicarbonate solution, water and sodium chloride solution
3. 3
   Autredried
4. 4
   Autrethe solvent was then removed

Mode opératoire

At from 0 to 5° C., a solution of 209.0 g (1.1 mol) of titanium tetrachloride in 150 ml of methylene chloride was added dropwise to a solution of 50.1 g (0.275 mol) of methyl 2-hydroxy-4-methoxybenzoate and 88 g (0.725 mol) of dichloromethoxymethane in 400 ml of methylene chloride, and the mixture was stirred at room temperature overnight. The mixture was then stirred into ice-water and extracted with methylene chloride. The combined organic phases were washed with sodium bicarbonate solution, water and sodium chloride solution and dried, and the solvent was then removed. Silica gel chromatography using cyclohexane/ethyl acetate=1:1 gave 24.5 g (42%) of methyl 2-hydroxy-3-formyl-4-methoxybenzoate in the form of a colorless solid of m.p.: 123–1240° C.

Source