Réaction #1328403

Équation de réaction

9-Fluorenone

hydrazine monohydrate

hydrochloric acid

→

9-fluorenone hydrazone

Rendement 74.0%

Solvants

2-propanol

Conditions de réaction

Traitement

1. 1
   Autreequipped with a reflux condenser and a mechanical stirrer
2. 2
   Températurethe mixture was refluxed for one hour
3. 3
   Filtrationthe crude solid product was harvested by filtration
4. 4
   LavageThe solid was washed with isopropanol
5. 5
   Autrerecrystallized from dioxane

Mode opératoire

9-Fluorenone (200 g, 1.1 mol, from Aldrich, Milwaukee, Wis.) and hydrazine monohydrate (160 ml, 3.3 mol, from Aldrich, Milwaukee, Wis.) were dissolved in 1000 ml of 2-propanol in a 2000 ml 2-neck round bottom flask equipped with a reflux condenser and a mechanical stirrer. Concentrated hydrochloric acid (4 ml) was then added, and the mixture was refluxed for one hour. The mixture was cooled slowly to room temperature, and the crude solid product was harvested by filtration. The solid was washed with isopropanol and then recrystallized from dioxane to obtain 150 g (74% yield) of 9-fluorenone hydrazone.

Source