Réaction #1303

Équation de réaction

4-bromophenylacetic acid

H2SO4

ethanol

K2CO3

→

title compound

Ethyl (4-bromophenyl)acetate

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   ConcentrationThe filtrate was concentrated in vacuo
3. 3
   workup.ADDITIONdiluted with Et2O (200 ml)
4. 4
   Lavagewashed with 10% aqueous NaHCO3 (10 ml) and brine (10 ml)
5. 5
   Séchagedried over MgSO4
6. 6
   Concentrationconcentrated in vacuo

Mode opératoire

A solution of 43 g (200 mmol) of 4-bromophenylacetic acid and 0.2 g of conc. H2SO4 in 470 ml of ethanol was refluxed for 16 hours. The reaction mixture was cooled to ambient temperature, stirred with 6 g of solid K2CO3 for 30 minutes and then filtered. The filtrate was concentrated in vacuo, diluted with Et2O (200 ml), washed with 10% aqueous NaHCO3 (10 ml) and brine (10 ml), dried over MgSO4 and concentrated in vacuo to give the title compound as a colorless oil.

Source