Réaction #1282

Équation de réaction

triethylamine

benzylchloroformate

(S)-1,3,4,5-tetrahydro-4-phthalimido-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester

ethanol

→

(S)-1,3,4,5-Tetrahydro-4-[[(phenylmethoxy)carbonyl]amino]-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester

Solvants

ethyl acetate

ethyl acetate

toluene

hydrazine hydrate

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   Autrefiltrate evaporated to dryness
3. 3
   Autreagain evaporated to dryness
4. 4
   Autreplaced in an ice bath
5. 5
   Autrethe mixture was partitioned between ethyl acetate-5% potassium bisulfate
6. 6
   LavageThe organic phase was washed successively with 5% potassium bisulfate, saturated sodium bicarbonate and saturated sodium chloride solutions
7. 7
   Séchagedried (sodium sulfate)
8. 8
   Autreevaporated to dryness
9. 9
   AutrePurification of the crude product by flash chromatography on silica gel (Whatmann LPS-1)
10. 10
    Lavageeluting with ethyl acetate:hexane (1:2)
11. 11
    Autregave 1.0747 g
12. 12
    AutreA sample crystallized from hexane
13. 13
    Autre[α]D =+87.2° (C=0.53, chloroform)

Mode opératoire

A solution of (S)-1,3,4,5-tetrahydro-4-phthalimido-3-oxo-2H-2-benzazepine-2-acetic acid, ethyl ester (1.67 g., 4.26 mmol.) in 1.0M hydrazine hydrate in ethanol (9.0 ml., 9.0 mmol.) was stirred at room temperature under argon for 36 hours. The mixture was diluted with an equal volume of ethyl acetate, filtered and filtrate evaporated to dryness. The residue was taken up in toluene and again evaporated to dryness. The colorless, semi-solid residue (1.81 g.) was taken up in dry methylene chloride (20 ml.), placed in an ice bath and treated successively with triethylamine (0.80 ml., 5.8 mmol.) and benzylchloroformate (0.77 ml., 5.4 mmol.). After stirring at 0° C. for 2 hours, the mixture was partitioned between ethyl acetate-5% potassium bisulfate. The organic phase was washed successively with 5% potassium bisulfate, saturated sodium bicarbonate and saturated sodium chloride solutions, dried (sodium sulfate), and evaporated to dryness. Purification of the crude product by flash chromatography on silica gel (Whatmann LPS-1) eluting with ethyl acetate:hexane (1:2) gave 1.0747 g. of product as a colorless foam; Rf =0.52 (ethyl acetate:toluene, 3:7). A sample crystallized from hexane had m.p. 80°-82° C.; [α]D =+87.2° (C=0.53, chloroform).

Source