Réaction #1275

Équation de réaction

sodium hydroxide

sulfuric acid

Trans-1,2-indandiol

acetonitrile

acetonitrile

Water

→

cis-1-amino-2-indanol

Rendement 63.0%

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was gradually warmed to 20° C. and aged to 3 hours
2. 2
   Températurethe mixture heated to reflux
3. 3
   AutreThe resulting solid was removed by filtration

Mode opératoire

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).

Source