Réaction #1273550

Équation de réaction

4-methylthiazole-5-carbaldehyde

potassium carbonate

(trifluoromethyl)trimethylsilane

→

2,2,2-trifluoro-1-(4-methylthiazol-5-yl)ethanol

Rendement 84.5%

Solvants

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   Autrereacted at room temperature for 2.2 hours
2. 2
   AutreThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

Mode opératoire

According to Reference Example 8-2, by use of 4-methylthiazole-5-carbaldehyde (300 mg, 2.36 mmol) dissolved in N,N-dimethylformamide (4 mL), potassium carbonate (65 mg, 0.47 mmol) and (trifluoromethyl)trimethylsilane (0.419 mL, 2.83 mmol), the mixture was stirred and reacted at room temperature for 2.2 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(4-methylthiazol-5-yl)ethanol (Compound DT) (393 mg, yield: 84%).

Source