Réaction #1269863

Équation de réaction

4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester

HCl

→

4-(2-Amino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride

Solvants

Et2O

CH2Cl2

Conditions de réaction

Traitement

1. 1
   Filtrationthe white cake was filtered
2. 2
   Lavagewashed with Et2O
3. 3
   Autredried at HV overnight
4. 4
   AutreThe crude (1.19 g) was used without purification

Mode opératoire

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

Source