Réaction #1269852

Équation de réaction

4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester

2-phenyl-1,3-thiazole-4-carboxylic acid

DIPEA

TBTU

→

desired product

Rendement 49.0%

4-{2-[(2-Phenyl-thiazole-4-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid ethyl ester

Rendement 49.0%

Solvants

DMF

DMF

DMF

Conditions de réaction

Traitement

1. 1
   Autrethe reaction mixture was directly purified by preparative HPLC (IV)

Mode opératoire

To a solution of 2-phenyl-1,3-thiazole-4-carboxylic acid (5.1 mg) and DIPEA (3 eq) in DMF (0.4 mL) was added TBTU (1.2 eq) in DMF (0.2 mL). Then, a solution of 4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester (5.4 mg, prepared as described in WO2006114774) in DMF (0.2 mL) was added. After stirring overnight at RT, the reaction mixture was directly purified by preparative HPLC (IV) to give 4.9 mg of the desired product.

Source