Réaction #1268587

Équation de réaction

3-Methyl-5-nitroisoquinoline

hydrogen

→

title compound

Rendement 45.0%

3-Methylisoquinolin-5-amine

Rendement 45.0%

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   Filtrationthe catalyst was filtered off
2. 2
   Lavagewashing with more methanol
3. 3
   AutreThe filtrate was evaporated
4. 4
   Autrepurified by flash column chromatography

Mode opératoire

3-Methyl-5-nitroisoquinoline (Description 44; 660 mg, 3.51 mmol) was dissolved in MeOH (30 ml) and PtO2 catalyst (120 mg) was added. The mixture was stirred for 1 hour 45 minutes under a balloon of hydrogen, then the catalyst was filtered off, washing with more methanol. The filtrate was evaporated and purified by flash column chromatography using as eluant 5% methanol in dichloromethane to give the title compound (250 mg).

Source