Réaction #1256750

Équation de réaction

diisopropylchlorosilane

magnesium

iodine

ammonium chloride

1-Bromo-3-methoxypropane

→

liquid

Rendement 103.1%

Diisopropyl(3-methoxypropyl)silane

Rendement 103.1%

Solvants

THF

THF

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGby stirring at room temperature for 1 hour
2. 2
   AutreAfter termination of exothermic reaction
3. 3
   ExtractionThe resultant mixture was extracted with pentane
4. 4
   Lavageby washing with water six times
5. 5
   Séchagedrying over sodium sulfate anhydrate
6. 6
   AutreThe solvent was removed under reduced pressure, whereby the Compound 60a

Mode opératoire

1-Bromo-3-methoxypropane (9.18 g, 60.0 mmol) was dissolved in THF (55 mL), and magnesium (1.53 g, 62.9 mmol) and iodine (catalytic amount) were added thereto, followed by stirring at room temperature for 20 minutes and at 55° C. for 5 minutes. The resultant mixture was added dropwise to diisopropylchlorosilane (8.88 mL, 52.0 mmol) in THF (65 mL) for 5 minutes, followed by stirring at room temperature for 1 hour. After termination of exothermic reaction, the resultant mixture was further stirred at 50° C. for 1.5 hours, and saturated aqueous ammonium chloride was added thereto. The resultant mixture was extracted with pentane, followed by washing with water six times and drying over sodium sulfate anhydrate. The solvent was removed under reduced pressure, whereby the Compound 60a was obtained as an yellow liquid (10.1 g, 89%).

Source