Réaction #1246015

Équation de réaction

[3-(2-cyano-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester

→

2-(6-Methylamino-1-pyridin-2-ylmethyl-1H-indol-3-ylsulfanyl)-benzonitrile

Solvants

toluene acetone

Conditions de réaction

Traitement

1. 1
   Autrethe product obtained in the previous step (0.150 g, 0.33 mmol)
2. 2
   Autreto give

Mode opératoire

v)—Following a procedure analogous to that described under step i of Example 2, the product obtained in the previous step (0.150 g, 0.33 mmol) was methylated to give, after column chromatography (toluene/acetone 8:2), [3-(2-cyano-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester (0.044 g).

Source