Réaction #1244272

Équation de réaction

alcohol

N-((1-(2-Hydroxyethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide

Ts2O

→

21

Rendement 34.1%

2-(4-((2-(2-Nitro-1H-imidazol-1-yl)acetamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl 4-methylbenzenesulfonate

Rendement 34.1%

Solvants

DCM

Conditions de réaction

Traitement

1. 1
   ConcentrationThe reaction was then concentrated to dryness
2. 2
   Autrepurified on a silica gel cartridge

Mode opératoire

To a round bottom flask was added the alcohol 20 (106 mg, 0.359 mmol), TEA (36.3 mg, 0.359 mmol) and DCM (10 mL). Ts2O (117 mg, 0.359 mmol) was added in one portion. The reaction was stirred at RT for 4 hrs. The reaction was then concentrated to dryness and purified on a silica gel cartridge using EtOAc:Hex as the eluent to afford 55 mg (34% yield) of 21 as a white solid. Mass Spec (lo-res): Calc'd for C17H19N7O6S: 449.11. found: 450.1 (M+H).

Source