Réaction #1244265

Équation de réaction

HCl

4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane

water

TsCl

→

14

Rendement 49.0%

3-Azido-2-hydroxypropyl 4-methylbenzenesulfonate

Rendement 49.0%

Solvants

diethyl ether

methanol

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated under reduced pressure
2. 2
   Autreto afford a yellow oil which
3. 3
   Autrewas used for the next step without purification
4. 4
   AutreAfter drying for 0.5 hr
5. 5
   workup.DISSOLUTIONthe residue was dissolved in CH2Cl2 (30 mL)
6. 6
   workup.ADDITIONwas treated with Bu2SnO (0.071 mg, 0.3 mmol)
7. 7
   workup.STIRRINGAfter stirring for 3 hr at room temperature
8. 8
   Autrethe organic layer was separated
9. 9
   ExtractionThe aqueous layer was extracted with CH2Cl2 (2×50 mL)
10. 10
    Lavagethe organic layer was consecutively washed with H2O (50 mL) and brine (50 mL)
11. 11
    Séchagedried over MgSO4
12. 12
    AutreThe solvent was removed under vacuum
13. 13
    Autrethe residue was purified on silica gel using 33% EtOAc/hexanes as the eluent

Mode opératoire

4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane 13 (2.2 g, 13.99 mmol) was dissolved in methanol (25 mL). To this solution was added a solution of HCl in diethyl ether (2M, 5 mL) at 0° C. The mixture was stirred at room temperature overnight, and then concentrated under reduced pressure to afford a yellow oil which was used for the next step without purification. After drying for 0.5 hr, the residue was dissolved in CH2Cl2 (30 mL) and was treated with Bu2SnO (0.071 mg, 0.3 mmol), followed by TsCl (2.86 g, 15.0 mmol) and TEA (2.2 mL, 16 mmol). After stirring for 3 hr at room temperature, water (30 mL) was added and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (2×50 mL) and the organic layer was consecutively washed with H2O (50 mL) and brine (50 mL) and dried over MgSO4. The solvent was removed under vacuum and the residue was purified on silica gel using 33% EtOAc/hexanes as the eluent to afford 1.86 g of 14 (48% yield) as a clear, colorless oil. 1H NMR (CDCl3, 400 MHz) δ: 7.77 (d, J=8.0 Hz, 2H), 7.34 (d, J=8.0 Hz, 2H), 3.96-4.09 (m, 3H), 3.31-3.40 (m, 2H), 2.43 (s, 3H). Mass Spec (lo-res): Calc'd for C10H13N3O4S: 271.06. found: 294.1 (M+Na+).

Source