Réaction #1224

Équation de réaction

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

Solvants

water

ethyl ether

Conditions de réaction

Traitement

1. 1
   Autrethe reaction medium evaporated to dryness
2. 2
   Autrethe residue obtained
3. 3
   AutreThe organic phase was decanted off
4. 4
   Séchagedried over magnesium sulfate
5. 5
   Autreevaporated
6. 6
   AutreThe residue obtained
7. 7
   Autrewas triturated in heptane
8. 8
   Filtrationfiltered
9. 9
   Autre4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

Mode opératoire

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

Source