Réaction #1198041

ord-5d00b3e42ba047d2bda9d7c35bcec18e

Équation de réaction

CCCCCC
hexane
CCOC(C)=O
ethyl acetate
CCCCCC
hexane
CCOC(C)=O
ethyl acetate
O=C1Cc2ccccc2N1c1cccc(F)c1
1-(3-fluorophenyl)-2(1H,3H)-indolone
→
CN(C)C=C1C(=O)N(c2cccc(F)c2)c2ccccc21
title product
CN(C)C=C1C(=O)N(c2cccc(F)c2)c2ccccc21
1-(3-Fluorophenyl)-3-(dimethylaminomethylene)-2(1H,3H)-indolone

Réactifs

CCCCCC
hexane
CCOC(C)=O
ethyl acetate
CCCCCC
hexane
CCOC(C)=O
ethyl acetate
O=C1Cc2ccccc2N1c1cccc(F)c1
1-(3-fluorophenyl)-2(1H,3H)-indolone

Réactifs

Aucun

Solvants

CCCCC.CCOCC
ether pentane

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

By the procedure of Example A1, but using 13:7 hexane:ethyl acetate and then 3:7 hexane:ethyl acetate as eluant and ether/pentane for crystallization, 1-(3-fluorophenyl)-2(1H,3H)-indolone (0.80 g, 3.5 mmoles) was converted to title product, 0.53 g, m.p. 87°-88.5°.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04977178uspto-grants-1990_12