Réaction #1193

Équation de réaction

10-(2-ethylhexyloxy)decanol

epichlorohydrin

NaOH

→

10-(2-ethylhexyloxy)decyl glycidyl ether

Rendement 82.6%

Solvants

hexane

Conditions de réaction

Traitement

1. 1
   AutreA 200-ml flask equipped with a stirrer
2. 2
   Températurereflux tube
3. 3
   AutreAfter the resultant reaction mixture
4. 4
   Lavagewas washed with water
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
6. 6
   Autrethe resultant residue was purified by column chromatography on silica gel

Mode opératoire

A 200-ml flask equipped with a stirrer, reflux tube and dropping funnel was charged with 24.8 g (87 mmol) of 10-(2-ethylhexyloxy)decanol, 17.7 g (0.191 mol) of epichlorohydrin, 1.4 g (4.4 mmol) of tetrabutylammonium bromide and 25 ml of hexane. While stirring the mixture at 40° C., 29.2 g (0.35 mol) of a 48% aqueous solution of NaOH were added dropwise over 3 hours. After completion of the dropping, the stirring was continued further for 2 hours at 40° C. After the resultant reaction mixture was washed with water, and the solvent was distilled off under reduced pressure, the resultant residue was purified by column chromatography on silica gel, thereby obtaining 24.6 g (yield: 82.6%) of 10-(2-ethylhexyloxy)decyl glycidyl ether.

Source