Réaction #1192

Équation de réaction

2-ethylhexyl bromide

1,10-decanediol

KOH

→

10-(2-ethylhexyloxy)decanol

Rendement 72.1%

Solvants

xylene

Conditions de réaction

Traitement

1. 1
   AutreA 1-liter flask equipped with a stirrer
2. 2
   workup.DISTILLATIONdistilling off water
3. 3
   Autreformed
4. 4
   Températurethe resulting mixture was heated
5. 5
   AutreAfter completion of the reaction
6. 6
   Lavagewashed with water
7. 7
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure
8. 8
   Autrethe resulting residue was purified by column chromatography on silica gel

Mode opératoire

A 1-liter flask equipped with a stirrer and distiller was charged with 25 g (0.14 mol) of 1,10-decanediol, 8.09 g (0.14 mol) of KOH and 300 ml of xylene, and the resultant mixture was heated at 120° C. for 1 hour, thereby distilling off water formed. To this reaction mixture, were added 23.1 g (0.12 mol) of 2-ethylhexyl bromide, and the resulting mixture was heated and stirred for 15 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and washed with water. After the solvent was distilled off under reduced pressure, the resulting residue was purified by column chromatography on silica gel, thereby obtaining 24.8 g (yield: 72%) of 10-(2-ethylhexyloxy)decanol.

Source