Réaction #11814

Équation de réaction

2-(3-amino-5-chloro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

4-bromo-butyric acid ethyl ester

sodium bicarbonate

potassium iodide

bromo-butyric acid ethyl ester

→

title compound

Rendement 36.3%

4-(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethl-piperazin-1-yl]-2-oxo-ethoxy}-pyridin-3-ylamino)-butyric acid ethyl ester

Rendement 36.3%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe reaction was stirred at 70° C. for 18 hours
2. 2
   TempératureThe reaction was cooled
3. 3
   Concentrationconcentrated in vacuo
4. 4
   Autrepurified via flash chromatography on silica gel

Mode opératoire

To a solution of 2-(3-amino-5-chloro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone (0.072 g, 0.18 mmol) in ethanol (1 mL) was added 4-bromo-butyric acid ethyl ester (0.030 mL, 0.21 mmol), sodium bicarbonate (0.031 g, 0.37 mmol) and potassium iodide (˜0.030 g). The resulting solution was stirred at 70° C. for 18 hours. Additional bromo-butyric acid ethyl ester (0.030 mL, 0.21 mmol) was added and the reaction was stirred at 70° C. for 18 hours. The reaction was cooled, concentrated in vacuo and purified via flash chromatography on silica gel to give the title compound (0.034 g).

Source