Réaction #11765

Équation de réaction

(5-chloro-2-methoxy-phenyl)-methanesulfonamide

boron tribromide

→

title compound

Rendement 86.8%

(5-Chloro-2-hydroxy-phenyl)-methanesulfonamide

Rendement 86.8%

Solvants

dichloroethane

Conditions de réaction

Traitement

1. 1
   AutreThe reaction was quenched with water, saturated with sodium chloride
2. 2
   Extractionextracted with ethyl acetate
3. 3
   SéchageThe organic layer was dried over sodium sulfate
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated

Mode opératoire

To a suspension of (5-chloro-2-methoxy-phenyl)-methanesulfonamide (0.03 g, 0.13 mmol) in dichloroethane (1.5 mL) was added boron tribromide solution (1M in dichloromethane, 0.26 mL, 0.26 mmol). The reaction was stirred for one hour at ambient temperature. The reaction was quenched with water, saturated with sodium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to give the title compound (0.025 g).

Source