Réaction #1171

Équation de réaction

4-Piperidinecarboxamide

benzyl bromide

→

N-benzyl-4-piperidinecarboxamide

Rendement 35.0%

Solvants

EtOAc

DMSO

Conditions de réaction

Traitement

1. 1
   Lavagewashed with 1N aq. HCl, 5N aq. NaOH
2. 2
   Séchagedried over MgSO4
3. 3
   Concentrationconcentrated

Mode opératoire

4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.

Source