Réaction #1164100

Équation de réaction

benzene

2-allylaminoacetaldehyde

benzene

5-t-butyl-1,3,4-thiadiazol-2-yl isocyanate

→

2-[1-allyl-3-(5-t-butyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde

Solvants

diethyl ether pentane

Conditions de réaction

Traitement

1. 1
   Autreequipped with a mechanical stirrer
2. 2
   Températurereflux condenser
3. 3
   TempératureThe reaction mixture was heated
4. 4
   Autreto yield an oil
5. 5
   Filtrationwas filtered through diatomaceous earth

Mode opératoire

A mixture of 5-t-butyl-1,3,4-thiadiazol-2-yl isocyanate dimer (8.7 grams), the diethyl acetate of 2-allylaminoacetaldehyde (8.0 grams) and benzene (30 ml) was charged into a glass reaction flask equipped with a mechanical stirrer and reflux condenser. The reaction mixture was heated with stirring for a period of about 15 minutes. After this time the reaction mixture was stripped of benzene to yield an oil. The oil was dissolved in a diethyl ether-pentane mixture and was filtered through diatomaceous earth. The filtrate was stripped of solvent to yield the desired product the diethyl acetal of 2-[1-allyl-3-(5-t-butyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde as a dark oil.

Source