Réaction #1163972

ord-989d736b5bf44961821c28526edda9b4

Équation de réaction

O=C(O)/C=C/C(=O)O
fumaric acid
COc1ccc(CN2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c(OC)c1OC.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O
ether
COc1ccc(CN2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c(OC)c1OC.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O
1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine dicitrate monohydrate
→
COc1ccc(CN2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c(OC)c1OC.O.O=C(O)/C=C/C(=O)O.O=C(O)/C=C/C(=O)O
1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine difumarate monohydrate
Rendement 92.1%

Réactifs

O=C(O)/C=C/C(=O)O
fumaric acid
COc1ccc(CN2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c(OC)c1OC.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O
ether
COc1ccc(CN2CCN(CCC(c3ccccc3)c3ccccc3)CC2)c(OC)c1OC.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O
1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine dicitrate monohydrate
—
methanol-ether

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

By adding a methanol-ether solution of 1.75 g (0.015 mole) of fumaric acid to 5 ml of the concentrated ether solution described above 3.6 g (92.1% yield) of 1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine difumarate monohydrate with a melting point of 196° -197°C was obtained.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US03957790uspto-grants-1976_05