Réaction #1163967

Équation de réaction

N-3,3-Diphenylpropylpiperazine

2,3,4-trimethoxybenzyl chloride

tributylamine

→

1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine

Rendement 91.2%

Solvants

ethylene glycol diethyl ether

Conditions de réaction

Traitement

1. 1
   Températurethe resulting solution was heated at the refluxing temperature for 2.5 hours
2. 2
   AutreThe reaction liquid
3. 3
   workup.WAITwas left
4. 4
   Températureto cool
5. 5
   Filtrationfiltered

Mode opératoire

N-3,3-Diphenylpropylpiperazine in the amount of 1.4 g (0.005 mole), 1.1 g (0.005 mole) of 2,3,4-trimethoxybenzyl chloride, and 0.93 g (0.005 mole) of tributylamine were dissolved in 10 ml of ethylene glycol diethyl ether, and the resulting solution was heated at the refluxing temperature for 2.5 hours. The reaction liquid was left to cool, and filtered, and concentration of the filtrate under reduced pressure produced 2.1 g of oily 1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine (91.2% yield).

Source