Réaction #1160940

Équation de réaction

1-cyclopropyl-6-fluoro-7-bromo-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

3-methylpiperazine

→

1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Rendement 50.6%

Solvants

N-methyl-2-pyrrolidone

Conditions de réaction

Traitement

1. 1
   workup.DISTILLATIONAfter the solvent is distilled off under reduced pressure, ethanol
2. 2
   workup.ADDITIONis added to the residue
3. 3
   Autrethe crystals are separated by filtration
4. 4
   Autreare recrystallized from ethyl acetate-ethanol

Mode opératoire

To a solution of 1-cyclopropyl-6-fluoro-7-bromo-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.58 g) in N-methyl-2-pyrrolidone (5 ml) is added 3-methylpiperazine (0.65 g), and the mixture is heated at 90° C. for 20 minutes. After the solvent is distilled off under reduced pressure, ethanol is added to the residue, and the crystals are separated by filtration and are recrystallized from ethyl acetate-ethanol to give 1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (310 mg), as white powdery crystals, m.p. 206°-208° C.

Source