Réaction #1154355

Équation de réaction

benzyl cyanoformate

diethylenetriamine

triethylamine

→

Bis[2-(benzyloxycarbonylamino)-ethyl]-amine

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   AutreAfter completion of the reaction, concentration
2. 2
   Autreby evaporation
3. 3
   Lavagethe organic phase is washed with sodium carbonate solution
4. 4
   Séchagedried with sodium sulfate
5. 5
   workup.ADDITIONThe filtrate is mixed with hexane
6. 6
   Filtrationthe precipitate is filtered off
7. 7
   Autredried

Mode opératoire

51.5 g (500 mmol) of diethylenetriamine and 139 ml (1 mol) of triethylamine are dissolved in dichloromethane and mixed at −20° C. with 161 g of benzyl cyanoformate (Fluka) in dichloromethane and then stirred overnight at room temperature. After completion of the reaction, concentration by evaporation is performed during draw-off, the residue is taken up in diethyl ether, the organic phase is washed with sodium carbonate solution and dried with sodium sulfate. The filtrate is mixed with hexane, the precipitate is filtered off and dried.

Source