Réaction #1154034

Équation de réaction

trifluoroacetic acid

1-(t-butoxycarbonyl)-3-[2-(2-fluoro-5-bromobenzyloxy)ethyl]piperidine

→

3-[2-(2-fluoro-5-bromobenzyloxy)ethyl]piperidine

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   AutreThe reaction mixture was partitioned between 1 M potassium carbonate and methylene chloride
2. 2
   ExtractionThe aqueous fraction was back extracted with methylene chloride
3. 3
   Séchagedried over sodium sulfate
4. 4
   AutreThe solvents were removed in vacuo

Mode opératoire

In a 1-ml round bottom flask 1-(t-butoxycarbonyl)-3-[2-(2-fluoro-5-bromobenzyloxy)ethyl]piperidine (0.495 g) was dissolved in methylene chloride (4 ml) under a nitrogen atmosphere. The solution was cooled to 0° C. and trifluoroacetic acid (1 ml) was slowly added dropwise. The resulting mixture was stirred for thirty minutes at ambient temperature. The progress of the reaction was monitored by thin layer chromatography. The reaction mixture was partitioned between 1 M potassium carbonate and methylene chloride. The aqueous fraction was back extracted with methylene chloride. The organic fractions were combined, and dried over sodium sulfate. The solvents were removed in vacuo. The resulting residue was used as is.

Source