Réaction #1135841

Équation de réaction

methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate

acetic acid

→

methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate

Rendement 67.7%

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated
2. 2
   AutreThe residue was purified by biotage column chromatography

Mode opératoire

To a solution of methyl 8-(2-(cyclopropylamino)phenylamino)-8-oxooctanoate (390 mg) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(1-cyclopropyl-1H-benzo[d]imidazol-2-yl)heptanoate (249 mg)

Source