Réaction #1135838

Équation de réaction

1-fluoro-2-nitrobenzene

cyclopropyl amine

→

N-cyclopropyl-2-nitroaniline

Rendement 96.2%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated
2. 2
   AutreThe residue was purified by biotage column chromatography

Mode opératoire

To a solution of 1-fluoro-2-nitrobenzene (0.50 g, 3.5 mmol) in ethanol was added cyclopropyl amine (0.60 g, 10.5 mmol). The solution was heated to 80° C. overnight and concentrated. The residue was purified by biotage column chromatography to give N-cyclopropyl-2-nitroaniline (0.60 g)

Source