Réaction #1135805

Équation de réaction

sodium bicarbonate

1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one

potassium carbonate

dimethyl sulfate

→

1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one

Solvants

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   AutreTo the reaction mixtures
2. 2
   Extractionthe mixtures were extracted with ethyl acetate
3. 3
   LavageThe organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   Séchagewere dried over anhydrous sodium sulfate
5. 5
   ConcentrationThe resulting mixtures were concentrated under reduced pressure

Mode opératoire

A mixture of the above-mentioned 1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one, potassium carbonate 17.40 g, dimethyl sulfate 5.78 g and N,N-dimethylformamide 150 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (hereinafter, referred to as “Intermediate (PRI-P)”) 8.10 g.

Source