Réaction #1135803

Équation de réaction

sodium nitrite

aluminium chloride

sodium azide

tetrahydrofuran

3-bromo-2-methylbenzoic acid chloride

tetrahydrofuran

hydrochloric acid

→

1-(2-methyl-3-bromophenyl)-1.4-dihydrotetrazole-5-one

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températurewith heating
2. 2
   Températureunder reflux for two hours
3. 3
   AutreAfter the reaction mixtures
4. 4
   Températurewere cooled under ice-
5. 5
   Températurecooling
6. 6
   workup.ADDITIONwas added
7. 7
   workup.STIRRINGthe resulting mixtures were stirred
8. 8
   Températurewith heating
9. 9
   Températureunder reflux for ten hours
10. 10
    TempératureAfter cooling the mixtures
11. 11
    workup.ADDITIONwas added
12. 12
    Autrethe reaction mixtures
13. 13
    workup.STIRRINGwith stirring
14. 14
    Extractionwere then extracted with ethyl acetate
15. 15
    SéchageThe organic layers were dried over anhydrous sodium sulfate
16. 16
    Concentrationwere then concentrated under reduced pressure

Mode opératoire

A mixture of aluminium chloride 181.0 g, sodium azide 265.0 g and tetrahydrofuran 30.0 mL was stirred with heating under reflux for two hours. After the reaction mixtures were cooled under ice-cooling, and thereto was added a mixture of the above-mentioned 3-bromo-2-methylbenzoic acid chloride and tetrahydrofuran 200 mL and the resulting mixtures were stirred with heating under reflux for ten hours. After cooling the mixtures, to a mixture of sodium nitrite 407 g and water 1,500 mL was added the reaction mixtures with stirring. The mixtures were acidified with concentrated hydrochloric acid and were then extracted with ethyl acetate. The organic layers were dried over anhydrous sodium sulfate and were then concentrated under reduced pressure to give 1-(2-methyl-3-bromophenyl)-1.4-dihydrotetrazole-5-one.

Source