Réaction #11347

Équation de réaction

Thionyl chloride

benzothiazole-6-sulfonic acid

dimethylformamide

→

6-Chlorosulfonylbenzothiazole

Solvants

dichloroethane

Conditions de réaction

Traitement

1. 1
   Températurethe reaction mixture was heated
2. 2
   Températureat reflux
3. 3
   Autreto yield a clear solution
4. 4
   Températureat reflux
5. 5
   Autrethe solvent was removed in vacuo and excess HCl and thionyl chloride
6. 6
   Autrewas chased by evaporation with dichloroethane

Mode opératoire

Thionyl chloride (4 mL) was added to a suspension of the benzothiazole-6-sulfonic acid (0.60 g, 2.79 mmol) in dichloroethane (15 mL) and the reaction mixture was heated at reflux and dimethylformamide (5 mL) was added to the reaction mixture to yield a clear solution. After 1.5 hr. at reflux, the solvent was removed in vacuo and excess HCl and thionyl chloride was chased by evaporation with dichloroethane.

Source