Réaction #11297

Équation de réaction

4-Bromophenol

potassium carbonate

benzyl bromide

→

4-benzyloxybromobenzene

Solvants

water

acetone

ethyl acetate

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction was refluxed under nitrogen
2. 2
   TempératureAfter 5–6 hours of reflux
3. 3
   Autrethe organic layer was separated
4. 4
   Séchagedried over magnesium sulfate
5. 5
   Autreevaporated to dryness
6. 6
   Autreto afford a white fluffy powder

Mode opératoire

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5–6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

Source